Asian Journal of Pharmaceutical Research

Mohd. Yaqub Khan ¹, Irfan Aziz ¹, Bipin Bihari ², Hemant Kumar ³, Maryada Roy ⁴, Vikas Kumar Verma ²

Affiliations
1 Azad Institute of Pharmacy and Research, Azadpur, Adjacent CRPF Camp, Bijnour, Lucknow-226002, Uttar Pradesh, IN
2 Saroj Institute of Technology and Management, Ahimamau P.O., Arjunganj Sultanpur Road, Lucknow-226002, Uttar Pradesh, IN
3 Hygia Institute of Pharmacy, Lucknow, Uttar Pradesh, IN
4 Mangalayatan University, Aligarh, Uttar Pradesh, IN

Abstract

Diabetes mellitus (DM), both insulin-dependent DM (IDDM) and non-insulin dependent DM (NIDDM) is a common and serious metabolic disorder throughout the world. Traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. Among many medications and other alternative medicines, several herbs have been known to cure and control diabetes; additionally they have no side effects. The present paper is an attempt to list of the plants with anti-diabetic and related beneficial effects originating from different parts of world. History showed that medicinal plants have been used in traditional healing around the world for a long time to treat diabetes; this is because such herbal plants have hypoglycemic properties and other beneficial properties, as reported in scientific literature. The medicinal plants, besides having natural therapeutic values against various diseases and considerable works have been done on these plants to treat diabetes mellitus, describes that the antidiabetic activity of medicinal plants is due to the presence of phenolic compounds, avonoids, terpenoids, coumarins and other constituents which show reduction in blood glucose levels. Some of these herbal plants and their active chemical constituents which have a role in the management of diabetes mellitus are compiled here and discussed in this review.

Keywords

Diabetes Mellitus, Hypoglycemic Agents, Herbal Medicines, Sulphonylureas, Biguanides.

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Mohd. Yaqub Khan ¹, Maryada Roy ¹, Raj Kumar Rawal ¹, Umesh Kumar Bansal ¹

Affiliations
1 Prosperity 6 Pharmaceutics, Plot No. 23, EPIP Phase 2, Thana, Baddi, Himachal Pradesh-173205, IN

Abstract

Ceftriaxone for injection, USP is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6R, 7R)-7-[2-(2-Amino-4-thiazolyl) glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio]methyl]-5-thia-1-zabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, 72-(Z)-(O-methyloxime), disodium salt, sesquaterhydrate. Ceftriaxone is a third-generation of cephalosporins which is used for community acquired infections such as pneumonia and urinaly tract infections. It showed great advantage of once-daily administration based on pharmacological manner and need no renal impairment. It is stable for β-lactamases against first- or second- generations of cephalosporins. Ceftriaxone is also used for streptococcal endocarditis as alternative first-line therapeutic regimen and used for Sexually Transmited Disease (STD) such as syphilis and chancoroid.

Keywords

Ceftriaxone, Cephalosporin, β-Lactamases.

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